Paper Key : IRJ************433
Author: Prajwal S. Musmade,Pratik V. Malvade,Sagar Gagre,Abhijit S. Navale
Date Published: 21 Jan 2023
Abstract
Tablets are a type of dosage form used for pharmaceuticals. It consists of an excipient powder mix and the active ingredient compressed or compacted into a fixed dose. Effective tableting aids may include diluents, binders or granulating agents, glidants (fluid aids), and glidants. Acceleration of tablet disintegration in the gastrointestinal tract. Flavorings or sweeteners to improve the taste. Pharmaceutical formulation goals to be achieved during work include tablets with long release times and strong physical strength. A tablet contains the highest concentration of medicinal ingredients while maintaining a constant unit of content per tablet. Multiple daily doses of the drug are required to keep the drug concentration within the therapeutic range. Increase patient compliance and avoid excessive dosing intervals. Development of a stable and safe oral formulation containing a time-release anti-inflammatory drug that can control arthritis. To determine the optimal dissolution profile for the dosage form being developed. Formulations were determined by comparing the in vitro dissolution profile to that of the innovative product. The aim of this study was to develop a pharmaceutically similar, stable, cost-effective, and improved-quality extended-release tablet formulation of etodolac. Polymers such as HPMC, ethylcellulose, Carbopol 934, MCC, and magnesium stearate are used to formulate tablets and conduct in vitro drug release studies.