Paper Key : IRJ************389
Author: Dr. John Chimerenka Ifenkwe
Date Published: 11 Jan 2023
Abstract
This research was carried out on 20 male albino rats. which were reared for a period of one year. They were divided into two groups of 10 rats in each group. Rats in group 1 were fed with normal diet (standard rodent laboratory chow -Coppens) and borehole water while rats in group 2 were fed with normal diet and water from the river in a crude oil impacted community (Igbeta-Ewoama). Levels of the following metals manganese, lead, cadmium, selenium, mercury and chromium as well as the oxidative stress biomarker 8 hydroxy -2- deoxyguanosine were measured in the two groups at the end of the experimental period.. Rats fed with water from the crtude oil impacted community (Group 2) had higher levels of the six metals that were measured than the control group. The differences in the measured values were statistically significant (p < 0.05).. Group 2 also had higher and significant levels of 8 hydroxy -2- deoxyguanosine. The results obtained show that there is bioaccumulation of the measured metals and also increase in the level of 8 hydroxy -2- deoxyguanosine in rats fed with water obtained from the river in the environment where crude oil drilling activities is carried out.
DOI LINK : 10.56726/IRJMETS32696 https://www.doi.org/10.56726/IRJMETS32696