Paper Key : IRJ************347
Author: Gaurav Uddhav Ahire,Mariya Babbar,Mohan Aaradhe,Nikita Ahire,Prof. Bhushan Wagh
Date Published: 14 Apr 2024
Abstract
Most frequently, drugs get delivered orally. But almost 40% of the new chemical entities show poor aqueous solubility depicting an unsatisfactory solubility. Lately, drug delivery methods that self-emulsify are generating a lot of interest.to upgrade the oral bioavailability of medications with low aqueous solubility.Drug delivery systems that self-emulsify (SEDDS) are one of the novel approaches to enhance the solubility and permeability of drugs belonging mainly to BCS class II (low solubility and high permeability) and IV (low solubility and low permeability). SEDDS is an isotropic mixture of surfactants, oil, solvents, co-solvents, or surfactants. The concept of this system is about their capacity to dilute by an aqueous phase and then form fine oil-in-water (ow) emulsions or micro-emulsions upon mild agitation through the gastrointestinal tract for lipophilic medications, which exhibit rate-limited disintegration. When liquid SEDDS are converted into solid dose forms like pills, capsules, or pellets, they become easier to give and more patient-friendly. By making the lipophilic medications more soluble, this method improves their bioavailability. An overview of the SEEDscomposition, mechanism, and application is provided in this article.