Paper Key : IRJ************897
Author: Purane Harshvardhan Ramdas
Date Published: 02 Apr 2024
Abstract
Curcumin, a naturally occurring polyphenolic compound derived from the Curcuma longa plant, has demonstrated remarkable therapeutic potential due to its anti-inflammatory, antioxidant, anti-cancer, and neuroprotective properties. However, its clinical utility has been limited by poor aqueous solubility and low bioavailability. In recent years, nanotechnology has emerged as a promising avenue to address these challenges. This review paper explores the use of nanoflowers as a novel approach to enhance the solubility and bioavailability of curcumin. Nanoflowers, characterized by their unique morphology and high surface area-to-volume ratio, offer numerous advantages in drug delivery applications. The synthesis methods, physicochemical properties, and biomedical applications of curcumin-loaded nanoflowers are discussed in detail. Furthermore, the mechanisms underlying the enhanced solubility and bioavailability of curcumin when formulated as nanoflowers are elucidated. Finally, the potential challenges and future directions in the development of curcumin-loaded nanoflowers for clinical translation are addressed.